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KMID : 0377819900100020217
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Diagnosis and Treatment
1990 Volume.10 No. 2 p.217 ~ p.224
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3YEARS´ EXPERIENCE OF CHORIONIC VILLUS SAMPLING
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Abstract
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Chorionic villus sampling for the first trimester prenatal diagnosis has the potential of becoming an attractive alternative to midtrimester amniocentesis. Prior to becoming a standard, however, con - siderable caution and monitoring is necessay´ to establish the accuracy and safety of the procedure. In this pursuit, we wish to present our experience and trial in the technical sapects and safety of chorionic villus sampling. Chorionic villi were ob - tained by transcervical catheter (Trophocan or S- fl or transabdominal 19 gauge spinal needle under the real-time ultrasound guidance. Both direct and cultivation method of chorionic villas for chromosome preparation were performed.
The patients consisted of 200 pregnant women who did genetic chorionic villus sampling in 8 to 14 weeks gestation with genetic indications
The results obtained were as follows :
1) The chromosomal abnormality was found in 9 cases(4.5 %) : 2 in 47, XX, -1-21, 1 in 47 , XX; +18, 2 in 1.5q partial trisomy, 2 in 47,.XXY, 1 in 45, X and 1 in 45, X / 47, XXX,
2) The fetal loss was found in 4 cases(2.0%),
These results suggest that chorionic villus sampling now be considered a viable and quite possibly an equal safe alternative to second trimester amniocentesis.
1) The chromosomal abnormality was found in 9 cases(4.5 %) : 2 in 47, XX, -1-21, 1 in 47 , XX; +18, 2 in 1.5q partial trisomy, 2 in 47,.XXY, 1 in 45, X and 1 in 45, X / 47, XXX,
2) The fetal loss was found in 4 cases(2.0%),
These results suggest that chorionic villus sampling now be considered a viable and quite possibly an equal safe alternative to second trimester amniocentesis.
1) The chromosomal abnormality was found in 9 cases(4.5 %) : 2 in 47, XX, -1-21, 1 in 47 , XX; +18, 2 in 1.5q partial trisomy, 2 in 47,.XXY, 1 in 45, X and 1 in 45, X / 47, XXX,
2) The fetal loss was found in 4 cases(2.0%),
These results suggest that chorionic villus sampling now be considered a viable and quite possibly an equal safe alternative to second trimester amniocentesis.
1) The chromosomal abnormality was found in 9 cases(4.5 %) : 2 in 47, XX, -1-21, 1 in 47 , XX; +18, 2 in 1.5q partial trisomy, 2 in 47,.XXY, 1 in 45, X and 1 in 45, X / 47, XXX,
2) The fetal loss was found in 4 cases(2.0%),
These results suggest that chorionic villus sampling now be considered a viable and quite possibly an equal safe alternative to second trimester amniocentesis.
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